Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.
Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.
Eric G. Bluemn,Ilsa M Coleman,24 Authors,P. Nelson
2017 · DOI: 10.1016/j.ccell.2017.09.003
Cancer Cell · 622 Citations
TLDR
Results indicate that FGF/MAPK blockade may be particularly efficacious against mPCs with an AR-null phenotype, and this work is concerned with double-negative PCs, which are notable for elevated FGF and MAPK pathway activity.