Ameliorative effects of aqueous and ethanol extracts of Curcuma longa rhizome on lead-induced toxicity in adult male Wistar rats

Lead as very common in the environment as heavy released through burning of various fuels, mining, and manufacturing of lead batteries. Therefore, constant exposure to lead predisposes people to lead induced toxicity with acute and prolonged exposure. This study investigated the ameliorative roles of Curcuma longa rhizome extracts (aqueous and ethanolic) on the haematological, erythrocyte osmotic fragility, plasma biochemistry and indicators of associated oxidative stress in the rats. Thirty-five adult male Wistar rats that weigh 150-190 g used in this experiment were randomly divided into seven groups, A to G which consist five rats in each group. The positive control (group A) was given distilled water, Group B rats were administered a dose of 150 mg/kg lead acetate only. Groups C-D rats were given 150 mg/kg lead acetate plus 100 and 200 mg/kg aqueous extract of Curcuma longa respectively, while group E and F rats were exposed to a dose of 150 mg/kg lead acetate with 100 and 200 mg