Adult Onset Leukodystrophy with Neuroaxonal Spheroids: Clinical, Neuroimaging and Neuropathologic Observations

Clinical, neuroimaging and pathological correlations of four women ages 34–50 years with adult onset leukodystrophy provide clinical‐pathologic support for association pathways linking distributed neural circuits sub‐serving cognition and lend further support to the notion that white matter disease alone can account for dementia.