Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.
G. Barbara,V. Stanghellini,9 Authors,R. Corinaldesi
2004 · DOI: 10.1053/J.GASTRO.2003.11.055
Gastroenterology · 1,429 Citations
TLDR
Only mast cells in close proximity to nerves were significantly correlated with severity and frequency of abdominal pain/discomfort, and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.