A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Hadas Keren-Shaul,A. Spinrad,11 Authors,I. Amit
2017 · DOI: 10.1016/j.cell.2017.05.018
Cell · 4,742 Citations
TLDR
A novel microglia type associated with neurodegenerative diseases (DAM) is described and it is revealed that the DAM program is activated in a two-step process that involves downregulation of microglian checkpoints, followed by activation of a Trem2-dependent program.