A reanalysis of cluster randomized trials showed interrupted time-series studies were valuable in health system evaluation.
A reanalysis of cluster randomized trials showed interrupted time-series studies were valuable in health system evaluation.
A. Fretheim,A. Fretheim,10 Authors,S. Soumerai
2015 · DOI: 10.1016/j.jclinepi.2014.10.003
Journal of Clinical Epidemiology · 107 Citations
TLDR
The ITS design is valuable for evaluation of health systems interventions, both when RCTs are not feasible and in the analysis and interpretation of data from C-RCTs, yielding effect estimates with overlapping 95% confidence intervals (CI) across different analytical methods.