A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction
A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction
David S Sparks,S. Saifzadeh,13 Authors,D. Hutmacher
2020 · DOI: 10.1038/s41596-019-0271-2
Nature Protocols · 122 Citations
TLDR
This protocol describes how to establish an ovine critical-size, segmental bone defect model to study bone regeneration and reconstruction and full results for peer-reviewed publication can be attained within 2 years.