A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
J. Satin,J. W. Kyle,4 Authors,R. Rogart
1992 · DOI: 10.1126/science.256.5060.1202
Science · 378 Citations
TLDR
The cardiac sodium channel α subunit (RHI) is less sensitive to tetrodotoxin and saxitoxin and more sensitive to cadmium than brain and skeletal muscle isoforms and the primary determinant of high-affinity TTX-STX binding is a critical aromatic residue at position 374.