A Meta-Analysis of Cytokines in Major Depression
A Meta-Analysis of Cytokines in Major Depression
Y. Dowlati,N. Herrmann,4 Authors,K. Lanctôt
2010 · DOI: 10.1016/j.biopsych.2009.09.033
Biological Psychiatry · 4,366 Citations
TLDR
A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.