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A co-module approach for elucidating drug-disease associations and revealing their molecular basis

Shiwen Zhao,Shao Li

2012 · DOI: 10.1093/bioinformatics/bts057
85 Citations

TLDR

This work proposes a novel presentation of drug-gene-disease relationship, a 'co-module', which is characterized by closely related drugs, diseases and genes, and develops a Bayesian partition method to identify drug-Gene-Disease co-modules underlying the gene closeness data.