A class of ruthenium(II) catalyst for asymmetric transfer hydrogenations of ketones.
A class of ruthenium(II) catalyst for asymmetric transfer hydrogenations of ketones.
Aidan M. Hayes,D. Morris,G. Clarkson,M. Wills
2005 · DOI: 10.1021/JA051486S
Journal of the American Chemical Society · 224 Citations
TLDR
Catalyst 3 is a significantly more active catalyst for this application than the untethered derivative, exhibits higher enantioselectivities across a range of substrates, and appears to be highly stable to the reaction conditions.