YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance.
YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance.
Frank Szulzewsky,E. Holland,V. Vasioukhin
2021 · DOI: 10.1016/j.ydbio.2020.12.018
Developmental Biology · 108 Citations
TLDR
The molecular functions of Yap1 and its roles in cancer are discussed, with a focus on the different mechanisms of de-regulation of YAP1 activity in human cancers, including inactivation of upstream Hippo pathway tumor suppressors, regulation by intersecting pathways, miRNAs, and viral oncogenes.