XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
A. Kaser,Ann-Hwee Lee,8 Authors,R. Blumberg
2008 · DOI: 10.1016/j.cell.2008.07.021
Cell · 1,398 Citations
TLDR
It is reported that XBP1 deletion in intestinal epithelial cells (IECs) results in spontaneous enteritis and increased susceptibility to induced colitis secondary to both Paneth cell dysfunction and an epithelium that is overly reactive to inducers of IBD such as bacterial products (flagellin) and TNFalpha.