Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.
K. Cadwell,Khushbu K. Patel,7 Authors,H. Virgin
2010 · DOI: 10.1016/j.cell.2010.05.009
Cell · 905 Citations
TLDR
It is demonstrated that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice, providing a specific example of how a virus-plus-susceptibility gene interaction can determine the phenotype of hosts carrying common risk alleles for inflammatory disease.