Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention.
Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention.
E. Mostaghel,Linda N. Geng,4 Authors,P. Nelson
2010 · DOI: 10.1158/0008-5472.CAN-09-2509
Cancer Research · 43 Citations
TLDR
It is suggested that AR levels may predict the chemopreventive efficacy of SRD5A inhibitors, and subjects could be resolved into distinct cohorts characterized by high or low expression of genes regulated by the androgen receptor (AR), based solely on AR transcript expression.