Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress.
Maxime Galloy,Andréanne Blondeau,12 Authors,Amélie Fradet-Turcotte
2025 · DOI: 10.1016/j.molcel.2025.07.013
Molecules and Cells · 1 Citations
TLDR
It is reported that mH2A1.2-ubiquitination prevents toxic RAD18 engagement at MUS81-dependent double-strand breaks (DSBs), which arise at collapsed forks in difficult-to-replicate sites experiencing prolonged arrest.
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