USP11 stabilizes RALY to promote FXYD5-mediated aerobic glycolysis and aggravate pancreatic cancer progression.
USP11 stabilizes RALY to promote FXYD5-mediated aerobic glycolysis and aggravate pancreatic cancer progression.
Hongmin Xie,Langxia Liao,3 Authors,Min Lu
2025 · DOI: 10.1016/j.yexcr.2025.114758
Experimental Cell Research · 0 Citations
TLDR
USP11 stabilized FXYD5 mRNA by promoting RALY deubiquitinated modification to increase PC cell aerobic glycolysis and exacerbate tumor progression, and elucidate the mechanism by which FXYD5 regulates aerobic glycolysis in PC.