UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
O. Malakhova,Keun-Il Kim,5 Authors,Dong-er Zhang
2006 · DOI: 10.1038/sj.emboj.7601149
EMBO Journal · 436 Citations
TLDR
It is shown that Ubp43 negatively regulates IFN signaling independent of its isopeptidase activity towards ISG15, and this data implicate Ubp 43 as a novel in vivo inhibitor of signal transduction pathways that are specifically triggered by type I IFN.