Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine.

The experiments suggest that open channel block ofNMDA receptors can provide a novel approach for measurement of both open probability and the first latency distribution for ion channel opening in response to the binding of agonists, and provide additional evidence suggesting that the delayed opening of NMDA receptor channels underlies slow activation and deactivation of responses to glutamate.