Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.
N. Bhowmick,M. Ghiassi,5 Authors,H. Moses
2001 · DOI: 10.1091/MBC.12.1.27
Molecular Biology of the Cell · 1,076 Citations
TLDR
The data suggest that TGF-beta rapidly activates RhoA-dependent signaling pathways to induce stress fiber formation and mesenchymal characteristics.