Transforming growth factor-beta induces development of the T(H)17 lineage.
Transforming growth factor-beta induces development of the T(H)17 lineage.
Paul R. Mangan,L. Harrington,7 Authors,C. Weaver
2006 · DOI: 10.1038/nature04754
Nature · 3,131 Citations
TLDR
Transforming growth factor-beta (TGF-beta) is identified as a cytokine critical for commitment to T(H)17 development and acts to upregulate IL-23R expression, thereby conferring responsiveness to IL-23.