Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord
Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord
Yunlong Xu,Yanjun Jiang,10 Authors,Yongjun Chen
2019 · DOI: 10.1007/s12264-019-00346-z
Neuroscience Bulletin · 25 Citations
TLDR
Intraperitoneal injection of Tα1 attenuated complete Freund’s adjuvant (CFA)-induced pain hypersensitivity, and decreased the up-regulation of pro-inflammatory cytokines in inflamed skin and the spinal cord suggest that T α1 plays a therapeutic role in inflammatory pain and in the modulation of microglia-induced pro- inflammatory cytokine production in addition to mediation of VGLUT and VGAT expression in the spinal Cord.