The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.
The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.
M. Rafestin-Oblin,A. Souque,3 Authors,A. Vandewalle
2003 · DOI: 10.1210/EN.2002-220708
Endocrinology · 96 Citations
TLDR
Cortisone and 11-dehydrocorticosterone, the main cortisol and corticosterone metabolites produced in the distal nephron, bind with high affinity to MR(L810), suggesting that cortisone is one of the endogenous steroids responsible for early-onset hypertension in men and nonpregnant women carrying the MR( L810) mutation.