The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
Monika Suchanek,R. Hynynen,6 Authors,V. Olkkonen
2007 · DOI: 10.1042/BJ20070176
Biochemical Journal · 156 Citations
TLDR
The present study identifies ORP1 and ORP2 as OSBPs and suggests that most of the mammalian ORPs are able to bind sterols.