The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.
The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.
Jennifer S. Park,J. Chu,4 Authors,Song Li
2011 · DOI: 10.1016/j.biomaterials.2011.02.019
Biomaterials · 744 Citations
TLDR
Insight is provided of how substrate stiffness differentially regulates stem cell differentiation, and have significant implications for the design of biomaterials with appropriate mechanical property for tissue regeneration.