The cyanobacterial toxin microcystin binds covalently to cysteine‐273 on protein phosphatase 1
The cyanobacterial toxin microcystin binds covalently to cysteine‐273 on protein phosphatase 1
R. Mackintosh,K. Dalby,3 Authors,C. MacKintosh
1995 · DOI: 10.1016/0014-5793(95)00888-G
FEBS Letters · 269 Citations
TLDR
It is demonstrated that Cys273 of PP1 binds covalently to the methyl‐dehydroalanine (Mdha) residue of the toxin, which explains the failure to detect this toxin post‐mortem in suspected cases of MC poisoning.