The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model
J. Wilkerson,M. Niphakis,9 Authors,A. Lichtman
2016 · DOI: 10.1124/jpet.115.229971
Journal of Pharmacology and Experimental Therapeutics · 58 Citations
TLDR
It is suggested that MAGL inhibition produces opiate-sparing events with diminished tolerance, constipation, and cannabimimetic side effects.