The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-41
The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-41
J. Wehkamp,Guoxing Wang,10 Authors,E. Stange
2007 · DOI: 10.4049/jimmunol.179.5.3109
Journal of Immunology · 264 Citations
TLDR
A reduced expression in ileal CD of the Wnt-signaling pathway transcription factor Tcf-4, a known regulator of Paneth cell differentiation and α-defensin expression, is reported, which provides a novel mechanism for pathogenesis in patients with ilesal CD.