The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
C. Sala Frigerio,L. Wolfs,16 Authors,B. de Strooper
2019 · DOI: 10.1016/j.celrep.2019.03.099
Cell Reports · 691 Citations
TLDR
Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female AppNL-G-F mice over time demonstrate that progressive amyloid-b accumulation accelerates two main activated microglia states that are also present during normal aging.