The Antimicrobial Peptide LL-37 Alters Human Osteoblast Ca2+ Handling and Induces Ca2+-Independent Apoptosis
The Antimicrobial Peptide LL-37 Alters Human Osteoblast Ca2+ Handling and Induces Ca2+-Independent Apoptosis
Johanna Säll,M. Carlsson,6 Authors,D. Jönsson
2013 · DOI: 10.1159/000346587
Journal of Innate Immunity · 57 Citations
TLDR
LL-37 reduces the osteoblast cell number by promoting apoptosis, and furthermore, LL-37 stimulates Ca-2+ inflow via a mechanism independent of voltage-sensitive Ca2+ channels.