The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Shipra Vaishnava,Miwako Yamamoto,6 Authors,L. Hooper
2011 · DOI: 10.1126/science.1209791
Science · 1,228 Citations
TLDR
It is shown that RegIIIγ, a secreted antibacterial lectin, is essential for maintaining a ~50-micrometer zone that physically separates the microbiota from the small intestinal epithelial surface.