The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population.
The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population.
Y. Giwercman,P. Abrahamsson,2 Authors,G. Ahlgren
2005 · DOI: 10.1016/J.EURURO.2005.06.011
European Urology · 49 Citations
TLDR
Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population, androgen receptor genotype affected CaP outcome.