Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf.
Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf.
N. Hirata,M. Tokunaga,2 Authors,H. Matsuda
2007 · DOI: 10.1248/BPB.30.2402
Biological and Pharmaceutical Bulletin · 49 Citations
TLDR
P. nigrum leaf extract showed in vivo anti-androgenic activity using the hair regrowth assay in testosterone sensitive male C57Black/6CrSlc strain mice and the 5alpha-reductase inhibitory activities of 1 and piperine were found for the first time.