Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases
Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases
M. Furukawa,Y. He,C. Borchers,Y. Xiong
2003 · DOI: 10.1038/ncb1056
Nature Cell Biology · 455 Citations
TLDR
It is shown that Cul3, but not other cullins, binds directly to multiple BTB domains through a conserved amino-terminal domain, suggesting that in vivo there exists a potentially large number of BCR3 (BTB–Cul3–Roc1) E3 ubiquitin ligases.