Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
O. Adachi,T. Kawai,5 Authors,S. Akira
1998 · DOI: 10.1016/S1074-7613(00)80596-8
Immunity · 2,329 Citations
TLDR
It is demonstrated that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor, and increases in interferon-gamma production and natural killer cell activity in response to IL- 18 are abrogated.