TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways
TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways
Junichi Matsumoto,S. Dohgu,5 Authors,Y. Kataoka
2018 · DOI: 10.1016/j.brainres.2018.04.023
Brain Research · 91 Citations
TLDR
Findings indicated that crosstalk between the IκB-NFκB and JAK-STAT3 pathways is a pericyte specific mechanism, not occurring in astrocytes, for TNF-α-induced IL-6 release, and suggest a potentially attractive therapeutic target for brain inflammation.