TLR Signaling Mediated by MyD88 Is Required for a Protective Innate Immune Response by Neutrophils to Citrobacter rodentium1
TLR Signaling Mediated by MyD88 Is Required for a Protective Innate Immune Response by Neutrophils to Citrobacter rodentium1
Sarah L. Lebeis,B. Bommarius,2 Authors,D. Kalman
2007 · DOI: 10.4049/jimmunol.179.1.566
Journal of Immunology · 208 Citations
TLDR
It is demonstrated for the first time that the TLR adaptor MyD88 is essential for survival and optimal immunity following infection, and evidence is provided for a protective role of innate immune signaling in infections caused by attaching and effacing pathogens.