Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
Sangwon Lee,Jungyuen Choi,7 Authors,J. Schlessinger
2018 · DOI: 10.1038/nature25010
Nature · 195 Citations
TLDR
The crystal structures of free and ligand-bound β-klotho extracellular regions are described that reveal the molecular mechanism that underlies the specificity of FGF21 towards β- Klotho and demonstrate how the FGFR is activated in a klotho-dependent manner.