Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.
D. Tillett,E. Dittmann,3 Authors,B. Neilan
2000 · DOI: 10.1016/S1074-5521(00)00021-1
Chemistry and Biology · 942 Citations
TLDR
This report is the first complete description of the biosynthesis pathway of a complex cyanobacterial metabolite and represents an integrated polyketide-peptide biosynthetic pathway with a number of unusual structural and enzyme features.