Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
Shawn Xiong,K. Lorenzen,9 Authors,F. Sicheri
2018 · DOI: 10.1016/j.str.2018.05.014
Structure · 19 Citations
TLDR
The crystal structure of the human NDR1 kinase domain in its non-phosphorylated state is reported, revealing a fully resolved atypically long activation segment that blocks substrate binding and stabilizes a non-productive position of helix αC.