Streptozotocin‐Induced Diabetic Models in Mice and Rats
Streptozotocin‐Induced Diabetic Models in Mice and Rats
B. Furman
TLDR
Protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats and creating animal models for type 2 diabetes using STZ are described.
Abstract
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. © 2015 by John Wiley & Sons, Inc.