Strategic Composition and Enrichment of the Mitochondrial Ca2+ Uniporter at Mitochondria-SR Associations Creates Hotspots for Mitochondrial Ca2+ Uptake in the Cardiac Muscle
Strategic Composition and Enrichment of the Mitochondrial Ca2+ Uniporter at Mitochondria-SR Associations Creates Hotspots for Mitochondrial Ca2+ Uptake in the Cardiac Muscle
S. G. L. Fuente,C. Vail,8 Authors,G. Csordás
2016 · DOI: 10.1016/J.BPJ.2015.11.1673
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TLDR
The data suggest a distribution bias in the mtCU channel components over the cardiac IMM, turning mitochondria-SR interfaces to Ca2+ uptake ‘hotspots’ harboring all-EMRE-supported MCU while leaving other IMM areas less responsive toCa2+ owing to EMRE-less mtCUs.