Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks
Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks
T. Murphy,R. Tussiwand,K. Murphy
2013 · DOI: 10.1038/nri3470
Nature reviews. Immunology · 357 Citations
TLDR
The capacity of the BATF leucine zipper regions to mediate dimerization with AP-1 factors and also to define cooperative interactions with heterologous factors explains both the positive transcriptional activity of BATF proteins and how they activate distinct sets of target genes compared with FOS.
