Sortase‐catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus
Sortase‐catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus
S. Mazmanian,H. Ton-That,O. Schneewind
2001 · DOI: 10.1046/j.1365-2958.2001.02411.x
Molecular Microbiology · 406 Citations
TLDR
Many surface proteins of Gram‐positive bacteria are anchored to the cell wall envelope by a transpeptidation mechanism, requiring a C‐terminal sorting signal with a conserved LPXTG motif, and it is conceivable that S. aureus has evolved more than one pathway for the transport of 20 surface proteins to thecell wall envelope.