Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
M. Nguyen,R. Marcellus,14 Authors,G. Shore
2007 · DOI: 10.1073/pnas.0709443104
Proceedings of the National Academy of Sciences of the United States of America · 660 Citations
TLDR
Findings support a rational clinical development opportunity for the compound in cancer indications or treatments where MCL-1 contributes to resistance to cell killing.