Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
M. Borghesan,J. Fafián-Labora,16 Authors,A. O’Loghlen
2019 · DOI: 10.1016/j.celrep.2019.05.095
Cell Reports · 227 Citations
TLDR
It is found that small extracellular vesicles (sEVs) contribute to paracrine senescence, and interferon-induced transmembrane protein 3 (IFITM3) is identified as being partially responsible for transmittingSenescence to normal cells.