Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
N. Sundaresan,Madhu Gupta,3 Authors,Mahesh P. Gupta
2009 · DOI: 10.1172/JCI39162
Journal of Clinical Investigation · 1,008 Citations
TLDR
It is shown that Sirt3 protects the mouse heart by blocking the cardiac hypertrophic response and is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS.