Short sirolimus half‐life in pediatric renal transplant recipients on a calcineurin inhibitor‐free protocol
Short sirolimus half‐life in pediatric renal transplant recipients on a calcineurin inhibitor‐free protocol
A. Schachter,A. Schachter,6 Authors,W. Harmon
2004 · DOI: 10.1046/j.1399-3046.2003.00148.x
Pediatric Transplantation · 68 Citations
TLDR
It is concluded that children require SRL dosing every 12’h, higher doses and frequent drug monitoring to achieve target SRL concentrations, and the T1/2 of SRL in pediatric renal transplant recipients not treated with CNI is much shorter than what has been reported for adults, due to rapid metabolism.