Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE).
Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE).
J. Norman,J. Yang,4 Authors,D. Livingston
1997 · DOI: 10.1089/JIR.1997.17.113
Journal of Interferon and Cytokine Research · 79 Citations
TLDR
In vivo blockade or genetic deletion of ICE inhibits pancreatitis-induced secretion of proinflammatory cytokines without altering IL-1 mRNA production and is associated with decreased pancreatitis severity and dramatic survival benefits.