Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
T. Ayabe,D. Satchell,3 Authors,A. Ouellette
2000 · DOI: 10.1038/77783
Nature Immunology · 920 Citations
TLDR
Paneth cells in mouse small intestinal crypts contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly.